Dimension Reduction

The three-dimensional (3D) organization of the genome is an important layer of regulation in developmental, disease, and evolutionary processes. Hi-C is a high-throughput chromosome conformation capture (3C) assay used to study the 3D genome by …

A poster introducing 3D genome and matrix factorization to a general audience

Three dimensional organization of the genome is emerging as an important determinant of cell-type specific expression and is implicated in many diseases, including cancer (Bouwman & de Laat 2015). Hi-C is a type of high-throughput chromosome …

Tutorial on dimension reduction methods at the Great Lakes Bioinformatics (GLBIO) conference

Three dimensional organization of the genome is emerging as an important determinant of cell-type specific expression and is implicated in many diseases, including cancer (Bouwman & de Laat 2015). Hi-C is a type of high-throughput chromosome …