3D Genome

GRiNCH: Graph-Regularized NMF and Clustering for Hi-C

How do we find structural units of DNA from its 3D conformation inside the cell?

Multiview NMF (MVNMF)

How do we identify genomic regions responsible for dynamic 3D organization of the DNA during development?

Tree-Guided Integrated Factorization (TGIF)

What are the persistent and dynamic structural elements of the 3D genome during a dynamic biological process?