Three-dimensional (3D) genome organization, which determines how the DNA is packaged inside the nucleus, has emerged as a key regulatory mechanism of cellular processes. High-throughput chromosomal conformation capture (Hi-C) technologies have …
Here we present GRiNCH, a novel matrix-factorization-based approach for simultaneous TAD discovery and smoothing of contact count matrices from high-throughput 3C data.
Three-dimensional (3D) genome organization, or how the DNA is packaged inside the nucleus, has emerged as a key regulatory mechanism of cellular function and malfunction. High-throughput chromosomal conformation capture (Hi-C) technologies have …
Three-dimensional (3D) genome organization, which determines how the DNA is packaged inside the nucleus, has emerged as a key regulatory mechanism of cellular processes. High-throughput chromosomal conformation capture (Hi-C) technologies have …
The three-dimensional (3D) organization of the genome is an important layer of regulation in developmental, disease, and evolutionary processes. Hi-C is a high-throughput chromosome conformation capture (3C) assay used to study the 3D genome by …