Tree-Guided Integrated Factorization (TGIF) is a pipeline designed to simultaneously analyze multiple input Hi-C datasets representing related biological conditions and identify conserved or context-specific structural elements that build up the 3D genome.
Three-dimensional (3D) genome organization, which determines how the DNA is packaged inside the nucleus, has emerged as a key regulatory mechanism of cellular processes. High-throughput chromosomal conformation capture (Hi-C) technologies have …
The three-dimensional (3D) organization of the genome, which determines how the DNA is packaged inside the nucleus, has emerged as a key regulatory mechanism of cellular function and malfunction. High-throughput chromosomal conformation capture …
Three-dimensional (3D) genome organization, which determines how the DNA is packaged inside the nucleus, has emerged as a key regulatory mechanism of cellular processes. High-throughput chromosomal conformation capture (Hi-C) technologies have …
To systematically identify higher-order changes in 3D genome organization linked to breast cancer development, we developed NE-MVNMF that combines network enhancement followed by multitask non-negative matrix factorization.